In a bowl, combine the mayo, ketchup, green relish, Frank's hot sauce, garlic powder, onion powder, and both salts and pepper. Mix well and set aside until needed.

Roll the ground beef into balls, each about 2 inches in diameter, placing them on a parchment-lined tray. You can also measure out each patty to approximately 2 oz.

Heat a cast iron or stainless steel pan over medium-high heat until hot. Prepare your burger balls and ensure they are spaced out on the griddle.

Place the burger balls on the hot surface and immediately smash them down to a thickness of about ½ inch using a firm spatula. Season liberally with salt and pepper.

Cook the patties for about one minute on the first side before flipping them and cooking for an additional 30 seconds. Be cautious not to overcook to avoid dryness.

Once flipped, season the other side, place cheese on top, and cover to help the cheese melt within those 30 seconds. Scrape any cheese that spills off back onto the burger.

Assemble your sliders by placing double patties on the buns with your favorite toppings such as lettuce, tomato, bacon, and pickles.