In a large skillet, heat a small amount of cooking oil over medium heat. Add the ground beef to the skillet and cook, breaking it apart with a spatula, until fully browned and cooked through, about 5-7 minutes.
Drain any excess fat from the skillet, then add the garlic powder, onion powder, salt, and black pepper. Stir to combine and cook for an additional 1-2 minutes to allow the spices to meld.
In a mixing bowl, combine the cooked beef, shredded cheddar cheese, diced tomatoes, diced onions, and chopped pickles. Mix in the mayonnaise, ketchup, and mustard until well combined.
Warm the flour tortillas in a microwave for about 15-20 seconds, just until they are pliable.
Spoon approximately ¼ of the cheeseburger filling onto the center of each tortilla. Fold in the sides and roll it up tightly from the bottom to enclose the filling.
If desired, place the rolled burritos seam-side down in the skillet and lightly grill them for 1-2 minutes on each side until golden brown. This will add a nice crunch to the tortillas.
Serve the cheeseburger burritos warm, with extra ketchup, mustard, or your favorite dipping sauces on the side.