In a small bowl, mix together paprika, onion powder, garlic powder, dried thyme, cayenne pepper, salt, and black pepper to create the spice mix for the salmon.
Pat the salmon fillets dry with paper towels. Rub the spice mix generously over both sides of each salmon fillet.
Heat olive oil in a cast iron skillet over medium-high heat until shimmering.
Carefully place the salmon fillets in the skillet and cook for 4-5 minutes on each side, or until the salmon is cooked through and has a blackened crust. Avoid overcrowding the skillet; cook in batches if necessary.
While the salmon is cooking, prepare the creamy Dijon sauce. In a separate mixing bowl, whisk together sour cream, Dijon mustard, lemon juice, honey, and season with salt and pepper to taste.
Once the salmon is done, remove it from the skillet and let it rest for a minute.
Serve the blackened salmon hot, topped with a generous spoonful of the creamy Dijon sauce.